CD24–p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages
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چکیده
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RLIM suppresses hepatocellular carcinogenesis by up-regulating p15 and p21
Hepatocellular carcinogenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation and apoptosis. p15 and p21 are cyclin-dependent kinase inhibitors, which arrest cell proliferation and serve as critical tumor suppressors. Here we report that the E3 ubiquitin ligase RLIM expression is downregulated in hepatocellular carcinoma patie...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2018
ISSN: 2056-5968
DOI: 10.1038/s41421-017-0007-9